| PLAYER | YEAR | ROUND | PICK | ORGANIZATION | DRAFTED FROM |
| Cole Tolbert | 2024 | 18 | 537 | Boston Red Sox | Ole Miss |
| Bryson Ware | 2023 | 8 | 253 | Philadelphia Phillies | Auburn |
| Landon Harper | 2022 | 14 | 425 | Atlanta Braves | Southern Miss |
| Colby White | 2019 | 6 | 188 | Tampa Bay Rays | Mississippi State |
| Dexter Jordan | 2019 | 16 | 496 | Houston Astros | Pearl River |
| Simon 'Meaux' Landry | 2018 | 22 | 674 | Los Angeles Dodgers | Pearl River |
| Zach Clark | 2016 | 19 | 561 | Milwaukee Brewers | Pearl River |
| Jacob Taylor | 2015 | 4 | 127 | Pittsburgh Pirates | Pearl River |
| Ryan Deemes | 2015 | 36 | 1069 | Houston Astros | Nicholls State |
| Taylor Byrd | 2014 | 7 | 201 | Seattle Mariners | Nicholls State |
| Braxton Lee | 2014 | 12 | 367 | Tampa Bay Rays | Ole Miss |
| Brandon Fry | 2013 | 18 | 538 | San Diego Padres | Pearl River |
| Christian Talley | 2013 | 26 | 788 | Tampa Bay Rays | Pearl RIver |
| Pat Daugherty | 2009 | 12 | 369 | St. Louis Cardinals | Pearl River |
| Kyle Maxie | 2007 | 28 | 873 | New York Mets | Pearl River |
| PJ Treadaway | 2005 | 42 | 1251 | Washington Nationals | Southeastern Louisiana |
| Rhyne Hughes | 2004 | 8 | 225 | Tampa Bay Rays | Pearl River |
| Thomas Royals | 2004 | 22 | 643 | Detroit Tigers | Pearl River |
| Craig Rodriguez | 2004 | 31 | 915 | Tampa Bay Rays | Ole Miss |
| Corey Bass | 2004 | 47 | 1408 | Houston Astros | Pearl River |
| Nick Tisone | 2003 | 19 | 552 | Kansas City Royals | Pearl River |
| Chad Catalano | 2003 | 32 | 941 | San Diego Padres | Pearl River |
| Rhyne Hughes | 2003 | 50 | 1465 | Pittsburgh Pirates | Pearl River |
| Wendell Magee | 1994 | 12 | 338 | Philadelphia Phillies | Samford |
| Brett Rossier | 1991 | 32 | 849 | New York Mets | Pearl River |
| Greg Elliot | 1989 | 56 | 1360 | Chicago White Sox | Southeastern Louisiana |
| Todd Russell | 1989 | 28 | 737 | Oakland Athletics | Pearl River |
| Jay Reeves | 1983 | 2 | 45 | Atlanta Braves | Pearl River |